Malaria Research Today is a free monthly online journal that collates and summarizes the latest research about Malaria, including details on prevention, treatment, causes, mosquitoes.

Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria.

Okoromah CA, Afolabi BB, Wall EC

Department of Paediatrics and Child Health, College of Medicine, University of Lagos, Idi-Araba, Surulere, Lagos, Lagos, Nigeria, PMB 12003.

Published 14 April 2011 in Cochrane Database Syst Rev, 4: CD004615.
Full-text of this article is available online (may require subscription).

Articles on Malaria published 17 March 2011:

Artesunate versus quinine for treating severe malaria.   Cochrane Database Syst Rev, 3: CD005967.

[Abstract] [Full-text]

Artesunate versus quinine for treating severe malaria.   Cochrane Database Syst Rev, 3: CD005967.

[Abstract] [Full-text]

Articles on Malaria published 14 March 2011:

Our impasse in developing a malaria vaccine.   Cell Mol Life Sci, 68(7): 1105-13.

Malaria presents a challenge to world health that to date has been beyond the abilities of researchers to conquer. This critique presents some of the strategies employed by the parasite to overcome immunity and the immunological challenges that we face to develop vaccines. A conclusion is that a vaccine must identify novel antigens or epitopes that are not normally immunogenic and which are therefore not under immune pressure and most likely to be conserved between different strains. Such ... [Abstract] [Full-text]

Articles on Malaria published 10 March 2011:

Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments.   BMC Public Health, 11: S9.

Vector-borne infections (VBI) are defined as infectious diseases transmitted by the bite or mechanical transfer of arthropod vectors. They constitute a significant proportion of the global infectious disease burden. United States (U.S.) Department of Defense (DoD) personnel are especially vulnerable to VBIs due to occupational contact with arthropod vectors, immunological naiveté to previously unencountered pathogens, and limited diagnostic and treatment options available in the austere and ... [Abstract] [Full-text]

Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments.   BMC Public Health, 11: S9.

Vector-borne infections (VBI) are defined as infectious diseases transmitted by the bite or mechanical transfer of arthropod vectors. They constitute a significant proportion of the global infectious disease burden. United States (U.S.) Department of Defense (DoD) personnel are especially vulnerable to VBIs due to occupational contact with arthropod vectors, immunological naiveté to previously unencountered pathogens, and limited diagnostic and treatment options available in the austere and ... [Abstract] [Full-text]

Articles on Malaria published 9 March 2011:

Uncertain outcomes: adjusting for misclassification in antimalarial efficacy studies.   Epidemiol Infect, 139(4): 544-51.

Evaluation of antimalarial efficacy is difficult because recurrent parasitaemia can be due to recrudescence or re-infection. PCR is used to differentiate between recrudescences and re-infections by comparing parasite allelic variants before and after treatment. However, PCR-corrected results are susceptible to misclassification: false positives, due to re-infection by the same variant present in the patient before treatment; and false negatives, due to variants that are present but too ... [Abstract] [Full-text]

Articles on Malaria published 21 February 2011:

Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs.   Exp Parasitol, 127(3): 609-26.

Malaria is a major public health problem in many tropical and subtropical countries and the burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs. There is an urgent need for discovery of new antimalarial agents. Herbal medicines for the treatment of various diseases including malaria are an important part of the cultural diversity and traditions of which Kenya's biodiversity has been an integral ... [Abstract] [Full-text]

Articles on Malaria published 18 February 2011:

Molecular correlates of experimental cerebral malaria detectable in whole blood.   Infect Immun, 79(3): 1244-53.

Cerebral malaria (CM) is a primary cause of deaths caused by Plasmodium falciparum in young children in sub-Saharan Africa. Laboratory tests based on early detection of host biomarkers in patient blood would help in the prognosis and differential diagnosis of CM. Using the Plasmodium berghei ANKA murine model of experimental cerebral malaria (ECM), we have identified over 300 putative diagnostic biomarkers of ECM in the circulation by comparing the whole-blood transcriptional profiles of ... [Abstract] [Full-text]

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