Malaria Research Today is a free monthly online journal that collates and summarizes the latest research about Malaria, including details on prevention, treatment, causes, mosquitoes.

Malaria virulence genes controlling expression through chromatin modification.

Deitsch KW

Department of Microbiology and Immunology, Weill Medical College, Cornell University, 1300 York Avenue, Box 62, New York, New York 10021, USA.

Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).

Published 11 April 2005 in Cell, 121(1): 1-2.
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